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With regard to the substantial clinical improvement criterion, the applicant asserted that SER-109 represents a substantial clinical improvement over existing technologies because SER-109 treats patients unresponsive to antibiotic treatment for rCDI and can be used in patients ineligible for ZINPLAVA TM due to CHF

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AMPK Pathway Dynamics: Frequently researched in molecular biology settings for its direct interaction with and activation of the AMP-activated protein kinase (AMPK) pathway

www.bmj.com/content/375/bmj.n2713.long